Association of mean platelet volume with incident type 2 diabetes mellitus risk: the Dongfeng-Tongji cohort study.

ABSTRACT: Background:Most of prior studies to demonstrate the association between mean platelet volume (MPV) and type 2 diabetes mellitus (T2DM) risk were cross-sectional design with inconsistent results. In the present prospective cohort study, we aimed to explore the relationship between MPV and incident T2DM risk among a middle-aged and older Chinese population. Methods:This prospective study included 14,009 individuals derived from the Dongfeng-Tongji cohort which was launched in 2008. A total of 997 incident T2DM patients were diagnosed during the mean 4.51 years of follow-up period. MPV levels were divided into quartiles. The adjusted hazard ratios (HRs) and 95% confidence intervals (95% CIs) of incident T2DM was estimated by Cox proportional hazard models. Results:Compared with study participants with MPV?

SUBMITTER: Li Z 

PROVIDER: S-EPMC5894209 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature