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A novel organ preservation solution with efficient clearance of red blood cells improves kidney transplantation in a canine model.


ABSTRACT: Organ preservation solutions are designed to minimize organ damage during transplantation. A novel preservation solution, WMO-II, was developed to have a low viscosity and to improve microvasculature perfusion for kidneys. In an autologous canine transplantation model, kidney function and recovery were evaluated after organs were flushed and cold-stored with WMO-II or HTK solution, a perfusate currently approved for clinical use. The average number of red blood cells remaining in a single glomerulus after flushing with WMO-II was significantly reduced when compared with HTK solution. Additionally, WMO-II reduced the number of apoptotic bodies in stored kidneys compared to HTK treated tissue after 48 h of cold storage by reducing expression of Caspase-9, BiP, Chop, and Caspase-12. WMO-II solution reduced serum creatinine levels and serum potassium in kidneys stored for 48 h when compared to HTK perfusion. WMO-II preserves kidney function as evidenced by the reduction in serum creatinine and potassium during graft transplantation.

SUBMITTER: Wang S 

PROVIDER: S-EPMC5894212 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature

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A novel organ preservation solution with efficient clearance of red blood cells improves kidney transplantation in a canine model.

Wang Sheng S   Gumpper Kristyn K   Tan Tao T   Luo Xianzhang X   Guo Hui H   Ming Changsheng C   Jiang Hanying H   Fang Jiangguo J   Du Guang G   Zhu Hua H   Ma Jianjie J   Chen Zhishui Z   Gong Nianqiao N  

Cell & bioscience 20180410


Organ preservation solutions are designed to minimize organ damage during transplantation. A novel preservation solution, WMO-II, was developed to have a low viscosity and to improve microvasculature perfusion for kidneys. In an autologous canine transplantation model, kidney function and recovery were evaluated after organs were flushed and cold-stored with WMO-II or HTK solution, a perfusate currently approved for clinical use. The average number of red blood cells remaining in a single glomer  ...[more]

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