Integrative Bioinformatics Approaches for Identification of Drug Targets in Hypertension.
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ABSTRACT:
SUBMITTER: Hemerich D
PROVIDER: S-EPMC5894467 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Publications
Integrative Bioinformatics Approaches for Identification of Drug Targets in Hypertension.
Hemerich Daiane D van Setten Jessica J Tragante Vinicius V Asselbergs Folkert W FW
Frontiers in cardiovascular medicine 20180404
High blood pressure or hypertension is an established risk factor for a myriad of cardiovascular diseases. Genome-wide association studies have successfully found over nine hundred loci that contribute to blood pressure. However, the mechanisms through which these loci contribute to disease are still relatively undetermined as less than 10% of hypertension-associated variants are located in coding regions. Phenotypic cell-type specificity analyses and expression quantitative trait loci show pred ...[more]
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