Dataset Information
Tranexamic acid in total hip arthroplasty: Mixed treatment comparisons of randomized controlled trials and cohort studies.
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ABSTRACT: Background
The present study is a network meta-analysis of various routes of tranexamic acid (TXA) in patients with total hip arthroplasty (THA).Methods
Randomized controlled trials and cohort studies evaluating TXA in patients with THA were included. Number of patients requiring blood transfusion was the primary outcome.Results
Pooled estimate for TXA use against placebo for blood transfusion rate was 0.30 [0.23, 0.39] favoring TXA. Maximum reduction in the risk of blood transfusion was observed with topical plus intra-operative intravenous TXA.Conclusion
Combined topical and intravenous TXA during surgery may perform better than other modes in patients undergoing THA.
SUBMITTER: Sridharan K
PROVIDER: S-EPMC5895930 | biostudies-literature | 2018 Mar
REPOSITORIES: biostudies-literature
Publications
Tranexamic acid in total hip arthroplasty: Mixed treatment comparisons of randomized controlled trials and cohort studies.
Journal of orthopaedics 20180117 1
<h4>Background</h4>The present study is a network meta-analysis of various routes of tranexamic acid (TXA) in patients with total hip arthroplasty (THA).<h4>Methods</h4>Randomized controlled trials and cohort studies evaluating TXA in patients with THA were included. Number of patients requiring blood transfusion was the primary outcome.<h4>Results</h4>Pooled estimate for TXA use against placebo for blood transfusion rate was 0.30 [0.23, 0.39] favoring TXA. Maximum reduction in the risk of blood ...[more]