Ontology highlight
ABSTRACT:
SUBMITTER: Maiques-Diaz A
PROVIDER: S-EPMC5896174 | biostudies-literature | 2018 Mar
REPOSITORIES: biostudies-literature
Cell reports 20180301 13
Pharmacologic inhibition of LSD1 promotes blast cell differentiation in acute myeloid leukemia (AML) with MLL translocations. The assumption has been that differentiation is induced through blockade of LSD1's histone demethylase activity. However, we observed that rapid, extensive, drug-induced changes in transcription occurred without genome-wide accumulation of the histone modifications targeted for demethylation by LSD1 at sites of LSD1 binding and that a demethylase-defective mutant rescued ...[more]