Dataset Information

Timing of Exercise Affects Glycemic Control in Type 2 Diabetes Patients Treated with Metformin.

ABSTRACT:

Objective

The purpose of the study was to examine the acute effects of the timing of exercise on the glycemic control during and after exercise in T2D.

Methods

This study included 26 T2D patients (14 women and 12 men) who were treated with metformin. All patients were tested on four occasions: metformin administration alone (Metf), high-intensity interval training (HIIT) performed at 30 minutes (EX30), 60 minutes (EX60), and 90 minutes (EX90) postbreakfast, respectively. Glucose, insulin, and superoxide dismutase (SOD) activity were examined.

Results

Glucose decreased significantly after the exercise in EX30, EX60, and EX90. Compared with Metf, the decline in glucose immediately after the exercise was larger in EX30 (-2.58?mmol/L; 95% CI, -3.36 to -1.79?mmol/L; p < 0.001), EX60 (-2.13?mmol/L; 95% CI, -2.91 to -1.34?mmol/L; p < 0.001), and EX90 (-1.87?mmol/L; 95% CI, -2.65 to -1.08?mmol/L; p < 0.001), respectively. Compared with Metf, the decrease in insulin was larger in EX30 and EX60 (both p < 0.001).

Conclusions

Timing of exercise is a factor to consider when prescribing exercise for T2D patients treated with metformin. This trial is registered with ChiCTR-IOR-16008469 on 13 May 2016.

SUBMITTER: Huang T

PROVIDER: S-EPMC5896215 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature

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Publications

Timing of Exercise Affects Glycemic Control in Type 2 Diabetes Patients Treated with Metformin.

Huang Tao T Lu Chunyan C Schumann Moritz M Le Shenglong S Yang Yifan Y Zhuang Haihui H Lu Qingwei Q Liu Jinsheng J Wiklund Petri P Cheng Sulin S

Journal of diabetes research 20180329

<h4>Objective</h4>The purpose of the study was to examine the acute effects of the timing of exercise on the glycemic control during and after exercise in T2D.<h4>Methods</h4>This study included 26 T2D patients (14 women and 12 men) who were treated with metformin. All patients were tested on four occasions: metformin administration alone (Metf), high-intensity interval training (HIIT) performed at 30 minutes (EX30), 60 minutes (EX60), and 90 minutes (EX90) postbreakfast, respectively. Glucose, ...[more]

PMID: 29785399

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Project description:Importance:Numerous factors are associated with the ability of patients with type 2 diabetes to achieve optimal glycemic control. However, many of these factors are not modifiable by quality improvement interventions. In contrast, the structure of how diabetes care is delivered, such as whether patients visit an endocrinologist or how prescriptions are filled, is potentially modifiable, yet its associations with glycemic control have not been rigorously evaluated. Objective:To investigate the association of diabetes care delivery with glycemic control in patients with type 2 diabetes using insulin. Design, Setting, and Participants:This retrospective cohort study used baseline claims and laboratory insurer data within a large pragmatic trial to identify individuals with type 2 diabetes using insulin with data for at least 1 hemoglobin A1c (HbA1c) test result from before trial randomization (July 1, 2014, to October 5, 2016) and for key nonmodifiable patient factors as well as diabetes care delivery and behavioral factors measured before the HbA1c test. Analyses were conducted from February 4, 2017, to November 13, 2018. Main Outcomes and Measures:Multivariable modified Poisson regression was used to evaluate the independent associations of nonmodifiable patient factors and potentially modifiable diabetes care delivery and patient behavioral factors with achieving adequate diabetes control (ie, HbA1c level <8%). The extent of measured variation explained in glycemic control by these factors was also explored using pseudo R2 and C statistics. Results:Of 1423 patients included, 565 (39.7%) were women, and the mean (SD) age was 56.4 (9.0) years. In total, 690 (48.5%) had HbA1c levels less than 8%. Age (relative risk [RR] per 1-unit increase, 1.01; 95% CI, 1.00-1.02), persistent use of basal insulin (RR, 1.20; 95% CI, 1.00-1.43), more frequent filling of glucose self-testing supplies (RR, 1.01; 95% CI, 1.01-1.02), visiting an endocrinologist (RR, 1.41; 95% CI, 1.19-1.67), and receipt of insulin prescriptions by mail order (RR, 1.23; 95% CI, 1.03-1.48) were all independently associated with adequate control. Measured potentially modifiable diabetes care factors explained more variation in adequate glycemic control than measured nonmodifiable patient factors (C statistic, 0.661 vs 0.598; pseudo R2 = 0.11 vs 0.04). Conclusions and Relevance:These findings suggest that for patients with type 2 diabetes using insulin, the way in which care is delivered may be more strongly associated with achieving adequate control of HbA1c levels than patient factors that cannot be altered are. Given the potential for intervention, these care delivery factors could be the focus of efforts to improve diabetes outcomes.

Dataset Information

Timing of Exercise Affects Glycemic Control in Type 2 Diabetes Patients Treated with Metformin.

Objective

Methods

Results

Conclusions

Publications

Timing of Exercise Affects Glycemic Control in Type 2 Diabetes Patients Treated with Metformin.

Similar Datasets

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