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FunResDB-A web resource for genotypic susceptibility testing of Aspergillus fumigatus.

ABSTRACT: Therapy of invasive aspergillosis is becoming more difficult due to the emergence of azole resistance in Aspergillus fumigatus. A majority of resistant strains carries mutations in the CYP51A gene. Due to a lack of sensitivity of culture-based methods, molecular detection of A. fumigatus has become an important diagnostic tool. We set up the database FunResDB (www.nrz-myk.de/funresdb) to gather all available information about CYP51A-dependent azole resistance from published literature. In summary, the screening resulted in 79 CYP51A variants, which are linked to 59 nonsynonymous mutations. A tailor-made online sequence analysis tool allows for genotypic susceptibility testing of A. fumigatus.

SUBMITTER: Weber M

PROVIDER: S-EPMC5896429 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature

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FunResDB-A web resource for genotypic susceptibility testing of Aspergillus fumigatus.

Weber Michael M Schaer Jonas J Walther Grit G Kaerger Kerstin K Steinmann Jörg J Rath Peter-Michael PM Spiess Birgit B Buchheidt Dieter D Hamprecht Axel A Kurzai Oliver O

Medical mycology 20180101 1

Therapy of invasive aspergillosis is becoming more difficult due to the emergence of azole resistance in Aspergillus fumigatus. A majority of resistant strains carries mutations in the CYP51A gene. Due to a lack of sensitivity of culture-based methods, molecular detection of A. fumigatus has become an important diagnostic tool. We set up the database FunResDB (www.nrz-myk.de/funresdb) to gather all available information about CYP51A-dependent azole resistance from published literature. In summar ...[more]

PMID: 28340175

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