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Leveraging Genomic Data in Smoking Cessation Trials in the Era of Precision Medicine: Why and How.

ABSTRACT:

Implications

This article outlines a framework for the consistent integration of biological data/samples into smoking cessation pharmacotherapy trials, aligned with the objectives of the recently unveiled Precision Medicine Initiative. Our goal is to encourage and provide support for treatment researchers to consider biosample collection and genotyping their existing samples as well as integrating genetic analyses into their study design in order to realize precision medicine in treatment of nicotine dependence.

SUBMITTER: Chen LS

PROVIDER: S-EPMC5896450 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature

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Leveraging Genomic Data in Smoking Cessation Trials in the Era of Precision Medicine: Why and How.

Chen Li-Shiun LS Zawertailo Laurie L Piasecki Thomas M TM Kaprio Jaakko J Foreman Marilyn M Elliott Hannah R HR David Sean P SP Bergen Andrew W AW Baurley James W JW Tyndale Rachel F RF Baker Timothy B TB Bierut Laura J LJ Saccone Nancy L NL

Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco 20180301 4

<h4>Implications</h4>This article outlines a framework for the consistent integration of biological data/samples into smoking cessation pharmacotherapy trials, aligned with the objectives of the recently unveiled Precision Medicine Initiative. Our goal is to encourage and provide support for treatment researchers to consider biosample collection and genotyping their existing samples as well as integrating genetic analyses into their study design in order to realize precision medicine in treatmen ...[more]

PMID: 28498934

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