Dataset Information

The Ups and Downs of Parenting Young Children With Type 1 Diabetes: A Crowdsourcing Study.

ABSTRACT:

Objectives

Parenting young children with type 1 diabetes (YC-T1D) entails pervasive challenges; parental coping may influence child and parent outcomes. This study used a qualitative descriptive design to describe these challenges comprehensively to inform the user-centered design of an Internet coping resource for parents.

Methods

A "Parent Crowd" of 153 parents of children with T1D onset at???5 years old submitted textual responses online to open-ended questions about parenting YC-T1D. Systematic coding organized responses into domains, themes, and examples. A supplemental focus group of racial/ethnic minority parents enhanced the sample's diversity and validated findings from the Parent Crowd.

Results

Similar domains and themes emerged from responses of crowdsourcing and focus group participants. In each domain, parenting YC-T1D was challenging, but there was also substantial evidence of positive coping strategies and adaptability.

Conclusions

The study yielded rich data to inform user-centered design of an Internet resource for parents of YC-T1D.

SUBMITTER: Pierce JS

PROVIDER: S-EPMC5896609 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature

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Publications

The Ups and Downs of Parenting Young Children With Type 1 Diabetes: A Crowdsourcing Study.

Pierce Jessica S JS Aroian Karen K Caldwell Cindy C Ross Judith L JL Lee Joyce M JM Schifano Elizabeth E Novotny Rebecca R Tamayo Anthony A Wysocki Tim T

Journal of pediatric psychology 20170901 8

<h4>Objectives</h4>Parenting young children with type 1 diabetes (YC-T1D) entails pervasive challenges; parental coping may influence child and parent outcomes. This study used a qualitative descriptive design to describe these challenges comprehensively to inform the user-centered design of an Internet coping resource for parents.<h4>Methods</h4>A "Parent Crowd" of 153 parents of children with T1D onset at ≤ 5 years old submitted textual responses online to open-ended questions about parenting ...[more]

PMID: 28369409

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Project description:Recent genome-wide analyses have uncovered a high accumulation of RNA polymerase II (Pol II) at the 5' end of genes. This elevated Pol II presence at promoters, referred to here as Poll II poising, is mainly (but not exclusively) attributed to temporal pausing of transcription during early elongation which, in turn, has been proposed to be a regulatory step for processes that need to be activated "on demand". Yet, the full genome-wide regulatory role of Pol II poising is yet to be delineated. To elucidate the role of Pol II poising in B cell activation, we compared Pol II profiles in resting and activated B cells. We found that while Pol II poised genes generally overlap functionally among different B cell states and correspond to the functional groups previously identified for other cell types, non-poised genes are B cell state specific. Focusing on the changes in transcription activity upon B cell activation, we found that the majority of such changes were from poised to non-poised state. The genes showing this type of transition were functionally enriched in translation, RNA processing and mRNA metabolic process. Interestingly, we also observed a transition from non-poised to poised state. Within this set of genes we identified several Immediate Early Genes (IEG), which were highly expressed in resting B cell and shifted from non-poised to poised state after B cell activation. Thus Pol II poising does not only mark genes for rapid expression in the future, but it is also associated with genes that are silenced after a burst of their expression. Finally, we performed comparative analysis of the presence of G4 motifs in the context of poised versus non-poised but active genes. Interestingly we observed a differential enrichment of these motifs upstream versus downstream of TSS depending on poising status. The enrichment of G4 sequence motifs upstream of TSS of non-poised active genes suggests a potential role of quadruplexes in expression regulation.

Dataset Information

The Ups and Downs of Parenting Young Children With Type 1 Diabetes: A Crowdsourcing Study.

Objectives

Methods

Results

Conclusions

Publications

The Ups and Downs of Parenting Young Children With Type 1 Diabetes: A Crowdsourcing Study.

Similar Datasets

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