Common and divergent features of galactose-1-phosphate and fructose-1-phosphate toxicity in yeast.
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ABSTRACT:
SUBMITTER: Gibney PA
PROVIDER: S-EPMC5896929 | biostudies-literature | 2018 Apr
REPOSITORIES: biostudies-literature
Publications
Common and divergent features of galactose-1-phosphate and fructose-1-phosphate toxicity in yeast.
Gibney Patrick A PA Schieler Ariel A Chen Jonathan C JC Bacha-Hummel Jessie M JM Botstein Maxim M Volpe Matthew M Silverman Sanford J SJ Xu Yifan Y Bennett Bryson D BD Rabinowitz Joshua D JD Botstein David D
Molecular biology of the cell 20180330 8
Metabolic dysregulation leading to sugar-phosphate accumulation is toxic in organisms ranging from bacteria to humans. By comparing two models of sugar-phosphate toxicity in Saccharomyces cerevisiae, we demonstrate that toxicity occurs, at least in part, through multiple, isomer-specific mechanisms, rather than a single general mechanism. ...[more]
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