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Membrane detachment is not essential for COG complex function.


ABSTRACT: COG is a multisubunit vesicle tethering complex in the Golgi. We demonstrate that both COG subcomplexes can be permanently attached to Golgi membranes and that major COG functions do not require cycling between the membrane and cytosol.

SUBMITTER: Climer LK 

PROVIDER: S-EPMC5896934 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature

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Membrane detachment is not essential for COG complex function.

Climer Leslie K LK   Pokrovskaya Irina D ID   Blackburn Jessica B JB   Lupashin Vladimir V VV  

Molecular biology of the cell 20180330 8


COG is a multisubunit vesicle tethering complex in the Golgi. We demonstrate that both COG subcomplexes can be permanently attached to Golgi membranes and that major COG functions do not require cycling between the membrane and cytosol. ...[more]

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