Serum interleukin-6 and tumor necrosis factor-α are associated with early graft regeneration after living donor liver transplantation.

ABSTRACT:

Background

Liver graft regeneration is orchestrated by specific and sequential stimuli, including hepatocyte growth factors, cytokines, and catecholamines. We evaluated the association between preoperative serum cytokines and early liver graft regeneration in human living donor liver transplantation (LDLT).

Patients and methods

We retrospectively reviewed the data of adult patients who underwent LDLT from January 2010 to December 2014. Serum cytokines, including interleukin (IL)-2, 6, 10, 12, 17, interferon (IFN)-γ and tumor necrosis factor (TNF)-α were measured in the recipients 1 day before surgery and on postoperative day (POD) 7. Liver graft volume was estimated using abdominal computed tomography images of the donors and recipients.

Results

In total, 226 patients

SUBMITTER: Chae MS 

PROVIDER: S-EPMC5896938 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature