Ontology highlight
ABSTRACT:
SUBMITTER: Baird TD
PROVIDER: S-EPMC5896957 | biostudies-literature | 2018 Mar
REPOSITORIES: biostudies-literature
Baird Thomas D TD Cheng Ken Chih-Chien KC Chen Yu-Chi YC Buehler Eugen E Martin Scott E SE Inglese James J Hogg J Robert JR
eLife 20180312
The nonsense-mediated mRNA decay (NMD) pathway detects aberrant transcripts containing premature termination codons (PTCs) and regulates expression of 5-10% of non-aberrant human mRNAs. To date, most proteins involved in NMD have been identified by genetic screens in model organisms; however, the increased complexity of gene expression regulation in human cells suggests that additional proteins may participate in the human NMD pathway. To identify proteins required for NMD, we performed a genome ...[more]