Ontology highlight
ABSTRACT:
SUBMITTER: Fyodorov DV
PROVIDER: S-EPMC5897046 | biostudies-literature | 2018 Mar
REPOSITORIES: biostudies-literature
Fyodorov Dmitry V DV Zhou Bing-Rui BR Skoultchi Arthur I AI Bai Yawen Y
Nature reviews. Molecular cell biology 20171011 3
Together with core histones, which make up the nucleosome, the linker histone (H1) is one of the five main histone protein families present in chromatin in eukaryotic cells. H1 binds to the nucleosome to form the next structural unit of metazoan chromatin, the chromatosome, which may help chromatin to fold into higher-order structures. Despite their important roles in regulating the structure and function of chromatin, linker histones have not been studied as extensively as core histones. Nevert ...[more]