Ontology highlight
ABSTRACT:
SUBMITTER: Zhang B
PROVIDER: S-EPMC5897412 | biostudies-literature | 2018 Apr
REPOSITORIES: biostudies-literature
Zhang Baozhu B Zhang Zhao Z Li Lei L Qin Yan-Ru YR Liu Haibo H Jiang Chen C Zeng Ting-Ting TT Li Meng-Qing MQ Xie Dan D Li Yan Y Guan Xin-Yuan XY Guan Xin-Yuan XY Zhu Ying-Hui YH
Nature communications 20180412 1
Beta-transducin repeat containing E3 ubiquitin protein ligase (BTRC) is crucial for the degradation of IκBα. Our previous transcriptome sequencing analysis revealed that tetraspanin 15 (TSPAN15) was significantly upregulated in clinical oesophageal squamous cell carcinoma (OSCC) tissues. Here, we show that high TSPAN15 expression in OSCC tissues is significantly associated with lymph node and distant metastasis, advanced clinical stage, and poor prognosis. Elevated TSPAN15 expression is, in part ...[more]