Cationic antimicrobial peptides do not change recombination frequency in Escherichia coli.
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ABSTRACT:
SUBMITTER: Rodriguez-Rojas A
PROVIDER: S-EPMC5897613 | biostudies-literature | 2018 Mar
REPOSITORIES: biostudies-literature
Publications
Cationic antimicrobial peptides do not change recombination frequency in <i>Escherichia coli</i>.
Rodríguez-Rojas Alexandro A Moreno-Morales Javier J Mason A James AJ Rolff Jens J
Biology letters 20180301 3
Cationic antimicrobial peptides are ubiquitous immune effectors of multicellular organisms. We previously reported, that in contrast to most of the classic antibiotics, cationic antimicrobial peptides (AMPs) do not increase mutation rates in <i>E. coli</i> Here, we provide new evidence showing that AMPs do not stimulate or enhance bacterial DNA recombination in the surviving fractions. Recombination accelerates evolution of antibiotic resistance. Our findings have implications for our understand ...[more]
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