Ontology highlight
ABSTRACT:
SUBMITTER: Foriel S
PROVIDER: S-EPMC5897729 | biostudies-literature | 2018 Mar
REPOSITORIES: biostudies-literature
Foriel Sarah S Beyrath Julien J Eidhof Ilse I Rodenburg Richard J RJ Schenck Annette A Smeitink Jan A M JAM
Disease models & mechanisms 20180327 3
Mitochondrial diseases are associated with a wide variety of clinical symptoms and variable degrees of severity. Patients with such diseases generally have a poor prognosis and often an early fatal disease outcome. With an incidence of 1 in 5000 live births and no curative treatments available, relevant animal models to evaluate new therapeutic regimes for mitochondrial diseases are urgently needed. By knocking down ND-18, the unique <i>Drosophila</i> ortholog of NDUFS4, an accessory subunit of ...[more]