Dataset Information

Toward Eradication of B-Vitamin Deficiencies: Considerations for Crop Biofortification.

ABSTRACT: 'Hidden hunger' involves insufficient intake of micronutrients and is estimated to affect over two billion people on a global scale. Malnutrition of vitamins and minerals is known to cause an alarming number of casualties, even in the developed world. Many staple crops, although serving as the main dietary component for large population groups, deliver inadequate amounts of micronutrients. Biofortification, the augmentation of natural micronutrient levels in crop products through breeding or genetic engineering, is a pivotal tool in the fight against micronutrient malnutrition (MNM). Although these approaches have shown to be successful in several species, a more extensive knowledge of plant metabolism and function of these micronutrients is required to refine and improve biofortification strategies. This review focuses on the relevant B-vitamins (B1, B6, and B9). First, the role of these vitamins in plant physiology is elaborated, as well their biosynthesis. Second, the rationale behind vitamin biofortification is illustrated in view of pathophysiology and epidemiology of the deficiency. Furthermore, advances in biofortification, via metabolic engineering or breeding, are presented. Finally, considerations on B-vitamin multi-biofortified crops are raised, comprising the possible interplay of these vitamins in planta.

SUBMITTER: Strobbe S

PROVIDER: S-EPMC5897740 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature

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Toward Eradication of B-Vitamin Deficiencies: Considerations for Crop Biofortification.

Strobbe Simon S Van Der Straeten Dominique D

Frontiers in plant science 20180406

'Hidden hunger' involves insufficient intake of micronutrients and is estimated to affect over two billion people on a global scale. Malnutrition of vitamins and minerals is known to cause an alarming number of casualties, even in the developed world. Many staple crops, although serving as the main dietary component for large population groups, deliver inadequate amounts of micronutrients. Biofortification, the augmentation of natural micronutrient levels in crop products through breeding or gen ...[more]

PMID: 29681913

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Project description:Biofortification breeding for three important micronutrients for human health, namely, iron (Fe), zinc (Zn), and provitamin A (PVA), has gained momentum in recent years. HarvestPlus, along with its global consortium partners, enhances Fe, Zn, and PVA in staple crops. The strategic and applied research by HarvestPlus is driven by product-based impact pathway that integrates crop breeding, nutrition research, impact assessment, advocacy, and communication to implement country-specific crop delivery plans. Targeted breeding has resulted in 393 biofortified crop varieties by the end of 2020, which have been released or are in testing in 63 countries, potentially benefitting more than 48 million people. Nevertheless, to reach more than a billion people by 2030, future breeding lines that are being distributed by Consultative Group on International Agricultural Research (CGIAR) centers and submitted by National Agricultural Research System (NARS) to varietal release committees should be biofortified. It is envisaged that the mainstreaming of biofortification traits will be driven by high-throughput micronutrient phenotyping, genomic selection coupled with speed breeding for accelerating genetic gains. It is noteworthy that targeted breeding gradually leads to mainstreaming, as the latter capitalizes on the progress made in the former. Efficacy studies have revealed the nutritional significance of Fe, Zn, and PVA biofortified varieties over non-biofortified ones. Mainstreaming will ensure the integration of biofortified traits into competitive varieties and hybrids developed by private and public sectors. The mainstreaming strategy has just been initiated in select CGIAR centers, namely, International Maize and Wheat Improvement Center (CIMMYT), International Rice Research Institute (IRRI), International Crops Research Institute for the Semi-Arid Tropics (ICRISAT), International Institute of Tropical Agriculture (IITA), and International Center for Tropical Agriculture (CIAT). This review will present the key successes of targeted breeding and its relevance to the mainstreaming approaches to achieve scaling of biofortification to billions sustainably.

Project description:In California, there is a shortage of good quality water available for irrigated agriculture due to severe drought. Consequently, saline groundwaters and drainage waters containing natural-occurring selenium (Se) and boron (B) salts are being considered as alternative sources of water for irrigation on salt and B tolerant crops like the edible halophyte-agretti (Salsola soda L.). In this multi-year field study, we evaluated agretti grown as a Se-biofortification crop in typical saline/B-laden soils (10 dS m−1 and 12 mg B/L) and irrigated with saline (3–8 dS m−1) and low-saline water (<1 d/S m) containing B (3–6 mg B/L) and Se (0.02–0.25 mg Se/L) at different evaporation transpiration (Eto) rates (100, 75, and 50 %, respectively). During the four-year study, fresh biomass yields ranged from 1 to 3 kg/m2 and were generally highest with irrigation at 100 % Eto with either saline or low-saline water. Tissue Se concentrations ranged from 2 to 3.2 mg Se / kg DW and 0.4–0.5 mg Se/kg DW with saline and low-saline irrigation, respectively. Selenium speciation in plant tissue showed the following: selenomethionine (SeMet) > selenate (SeO4) > methylselenocysteine (MeSeCys), irrespective of any treatment (i.e., year of planting, saline or low saline irrigation, rate of water application, direct seeding or transplanted). Agretti did not exhibit any toxicity symptoms as indicated by changes in total phenolic concentrations. Total phenolics ranged from 180 to 257 GAE/L and showed no significant differences among all treatments, although they were generally higher at the lowest water treatment (50% Eto). In regard to toxic ion accumulation, agretti tolerated excessive sodium (Na) and boron (B) and tissue concentrations ranging from 5.5 to 8.8% Na and 60 to 235 mg B/kg DW, respectively. Results from this multi-year study have identified a unique Se-biofortification strategy for producing Se-enriched agretti using saline, B- and Se-laden soil and irrigating with saline and low-saline water, respectively. Successful production of this crop may promote Se- biofortification strategies in poor quality regions where natural- occurring Se is present in soils and in waters used for irrigation.

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Dataset Information

Toward Eradication of B-Vitamin Deficiencies: Considerations for Crop Biofortification.

Publications

Toward Eradication of B-Vitamin Deficiencies: Considerations for Crop Biofortification.

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