Ontology highlight
ABSTRACT:
SUBMITTER: Rejmund M
PROVIDER: S-EPMC5898707 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Rejmund Marta M Mrozek-Wilczkiewicz Anna A Malarz Katarzyna K Pyrkosz-Bulska Monika M Gajcy Kamila K Sajewicz Mieczyslaw M Musiol Robert R Polanski Jaroslaw J Polanski Jaroslaw J
PloS one 20180413 4
A new class of TSCs containing piperazine (piperazinylogs) of Triapine, was designed to fulfill the di-substitution pattern at the TSCs N4 position, which is a crucial prerequisite for the high activity of the previously obtained TSC compounds-DpC and Dp44mT. We tested the important physicochemical characteristics of the novel compounds L1-L12. The studied ligands are neutral at physiological pH, which allows them to permeate cell membranes and bind cellular Fe pools more readily than less lipid ...[more]