Ontology highlight
ABSTRACT:
SUBMITTER: Stefanini I
PROVIDER: S-EPMC5899093 | biostudies-literature | 2018 Apr
REPOSITORIES: biostudies-literature
Scientific reports 20180413 1
Fungal infections represent an increasingly relevant clinical problem, primarily because of the increased survival of severely immune-compromised patients. Despite the availability of active and selective drugs and of well-established prophylaxis, classical antifungals are often ineffective as resistance is frequently observed. The quest for anti-fungal drugs with novel mechanisms of action is thus important. Here we show that a new compound, 089, acts by arresting fungal cells in the G2 phase o ...[more]