Dataset Information

Susceptibility to short-term ozone exposure and cardiovascular and respiratory mortality by previous hospitalizations.

ABSTRACT:

Background

Ozone (O₃) has been associated with cardiorespiratory mortality although few studies have explored susceptible populations based on prior disease. We aimed to investigate the role of previous hospitalization on the association between short-term exposure to O₃ and cardiovascular (CV) and respiratory mortality.

Methods

We performed time series analyses using generalized additive models and case-crossover on 136,624 CV and 23,281 respiratory deaths in Stockholm County (1990-2010). Deaths were linked to hospital admissions data. We constructed 2-day and 7-day averages using daily 8-h maximum for O₃ and hourly values for PM_2.5, PM₁₀, NO₂, and NO_x from a fixed monitor.

Results

We observed a 0.7% (95% CI: 0.1%, 1.3%) and 2.7% (95% CI: 0.8%, 4.6%) higher risk of CV and respiratory death per 10 ?g/m³ higher 2-day and 7-day average O₃ respectively. Individuals previously hospitalized for myocardial infarction demonstrated 1.8% (95% CI: 0.4%, 3.4%) higher risk of CV death per 10 ?g/m³ higher 2-day average O₃ and similar associations were observed in individuals with no previous hospitalization for any cause. Individuals with previous hospitalizations did not show susceptibility towards O₃-related risk of respiratory mortality. We observed no associations for other pollutants.

Conclusion

Short-term ozone exposure is associated with CV and respiratory mortality and our results may suggest higher susceptibility to CV mortality following O₃ exposure in individuals previously hospitalized for myocardial infarction. Higher risks were also observed in individuals with cardiovascular death as their first presentation of disease.

SUBMITTER: Raza A

PROVIDER: S-EPMC5899411 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature

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Publications

Susceptibility to short-term ozone exposure and cardiovascular and respiratory mortality by previous hospitalizations.

Raza Auriba A Dahlquist Marcus M Lind Tomas T Ljungman Petter L S PLS

Environmental health : a global access science source 20180413 1

<h4>Background</h4>Ozone (O<sub>3</sub>) has been associated with cardiorespiratory mortality although few studies have explored susceptible populations based on prior disease. We aimed to investigate the role of previous hospitalization on the association between short-term exposure to O<sub>3</sub> and cardiovascular (CV) and respiratory mortality.<h4>Methods</h4>We performed time series analyses using generalized additive models and case-crossover on 136,624 CV and 23,281 respiratory deaths i ...[more]

PMID: 29653570

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Project description:Although many studies have linked elevations in tropospheric ozone to adverse health outcomes, the effect of long-term exposure to ozone on air pollution-related mortality remains uncertain. We examined the potential contribution of exposure to ozone to the risk of death from cardiopulmonary causes and specifically to death from respiratory causes.Data from the study cohort of the American Cancer Society Cancer Prevention Study II were correlated with air-pollution data from 96 metropolitan statistical areas in the United States. Data were analyzed from 448,850 subjects, with 118,777 deaths in an 18-year follow-up period. Data on daily maximum ozone concentrations were obtained from April 1 to September 30 for the years 1977 through 2000. Data on concentrations of fine particulate matter (particles that are < or = 2.5 microm in aerodynamic diameter [PM(2.5)]) were obtained for the years 1999 and 2000. Associations between ozone concentrations and the risk of death were evaluated with the use of standard and multilevel Cox regression models.In single-pollutant models, increased concentrations of either PM(2.5) or ozone were significantly associated with an increased risk of death from cardiopulmonary causes. In two-pollutant models, PM(2.5) was associated with the risk of death from cardiovascular causes, whereas ozone was associated with the risk of death from respiratory causes. The estimated relative risk of death from respiratory causes that was associated with an increment in ozone concentration of 10 ppb was 1.040 (95% confidence interval, 1.010 to 1.067). The association of ozone with the risk of death from respiratory causes was insensitive to adjustment for confounders and to the type of statistical model used.In this large study, we were not able to detect an effect of ozone on the risk of death from cardiovascular causes when the concentration of PM(2.5) was taken into account. We did, however, demonstrate a significant increase in the risk of death from respiratory causes in association with an increase in ozone concentration.

Dataset Information

Susceptibility to short-term ozone exposure and cardiovascular and respiratory mortality by previous hospitalizations.

Background

Methods

Results

Conclusion

Publications

Susceptibility to short-term ozone exposure and cardiovascular and respiratory mortality by previous hospitalizations.

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