Ontology highlight
ABSTRACT:
SUBMITTER: Kabraji S
PROVIDER: S-EPMC5899637 | biostudies-literature | 2018 Apr
REPOSITORIES: biostudies-literature
Kabraji Sheheryar S Ni Jing J Lin Nancy U NU Xie Shaozhen S Winer Eric P EP Zhao Jean J JJ
Clinical cancer research : an official journal of the American Association for Cancer Research 20180206 8
The brain is the most common site of first metastasis for patients with HER2-positive breast cancer treated with HER2-targeting drugs. However, the development of effective therapies for breast cancer brain metastases (BCBM) is limited by an incomplete understanding of the mechanisms governing drug sensitivity in the central nervous system. Pharmacodynamic data from patients and <i>in vivo</i> models suggest that inadequate drug penetration across the "blood-tumor" barrier is not the whole story ...[more]