The limbic and neocortical contribution of α-synuclein, tau, and amyloid β to disease duration in dementia with Lewy bodies.
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ABSTRACT: Introduction
We sought to assess the individual and combined contribution of limbic and neocortical α-synuclein, tau, and amyloid β (Aβ) to duration of illness in dementia with Lewy bodies (DLB).Methods
Quantitative digital pathology of limbic and neocortical α-synuclein, tau, and Aβ was assessed in 49 patients with clinically probable DLB. Regression modeling examined the unique and shared contribution of each pathology to the variance of illness duration.Results
Patients with diffuse Lewy body disease had more severe pathology of each type and a shorter duration of illness than individuals with transitional Lewy body disease. The three pathologies accounted for 25% of the total variance of duration of illness, with 19% accounted for by α-synuclein alone or in combination with tau and Aβ. When the diffuse Lewy body disease group was examined separately, α-synuclein deposition significantly exceeded that of tau and Aβ. In this model, 20% of 24% total variance in the model for duration of illness was accounted for independently by α-synuclein.Discussion
In DLB, α-synuclein is an important predictor of disease duration, both independently and synergistically with tau and Aβ.
SUBMITTER: Ferman TJ
PROVIDER: S-EPMC5899889 | biostudies-literature | 2018 Mar
REPOSITORIES: biostudies-literature
Publications
The limbic and neocortical contribution of α-synuclein, tau, and amyloid β to disease duration in dementia with Lewy bodies.
Ferman Tanis J TJ Aoki Naoya N Crook Julia E JE Murray Melissa E ME Graff-Radford Neill R NR van Gerpen Jay A JA Uitti Ryan J RJ Wszolek Zbigniew K ZK Graff-Radford Jonathan J Pedraza Otto O Kantarci Kejal K Boeve Bradley F BF Dickson Dennis W DW
Alzheimer's & dementia : the journal of the Alzheimer's Association 20171031 3
<h4>Introduction</h4>We sought to assess the individual and combined contribution of limbic and neocortical α-synuclein, tau, and amyloid β (Aβ) to duration of illness in dementia with Lewy bodies (DLB).<h4>Methods</h4>Quantitative digital pathology of limbic and neocortical α-synuclein, tau, and Aβ was assessed in 49 patients with clinically probable DLB. Regression modeling examined the unique and shared contribution of each pathology to the variance of illness duration.<h4>Results</h4>Patient ...[more]
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