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The limbic and neocortical contribution of ?-synuclein, tau, and amyloid ? to disease duration in dementia with Lewy bodies.


ABSTRACT: INTRODUCTION:We sought to assess the individual and combined contribution of limbic and neocortical ?-synuclein, tau, and amyloid ? (A?) to duration of illness in dementia with Lewy bodies (DLB). METHODS:Quantitative digital pathology of limbic and neocortical ?-synuclein, tau, and A? was assessed in 49 patients with clinically probable DLB. Regression modeling examined the unique and shared contribution of each pathology to the variance of illness duration. RESULTS:Patients with diffuse Lewy body disease had more severe pathology of each type and a shorter duration of illness than individuals with transitional Lewy body disease. The three pathologies accounted for 25% of the total variance of duration of illness, with 19% accounted for by ?-synuclein alone or in combination with tau and A?. When the diffuse Lewy body disease group was examined separately, ?-synuclein deposition significantly exceeded that of tau and A?. In this model, 20% of 24% total variance in the model for duration of illness was accounted for independently by ?-synuclein. DISCUSSION:In DLB, ?-synuclein is an important predictor of disease duration, both independently and synergistically with tau and A?.

SUBMITTER: Ferman TJ 

PROVIDER: S-EPMC5899889 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature

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The limbic and neocortical contribution of α-synuclein, tau, and amyloid β to disease duration in dementia with Lewy bodies.

Ferman Tanis J TJ   Aoki Naoya N   Crook Julia E JE   Murray Melissa E ME   Graff-Radford Neill R NR   van Gerpen Jay A JA   Uitti Ryan J RJ   Wszolek Zbigniew K ZK   Graff-Radford Jonathan J   Pedraza Otto O   Kantarci Kejal K   Boeve Bradley F BF   Dickson Dennis W DW  

Alzheimer's & dementia : the journal of the Alzheimer's Association 20171031 3


<h4>Introduction</h4>We sought to assess the individual and combined contribution of limbic and neocortical α-synuclein, tau, and amyloid β (Aβ) to duration of illness in dementia with Lewy bodies (DLB).<h4>Methods</h4>Quantitative digital pathology of limbic and neocortical α-synuclein, tau, and Aβ was assessed in 49 patients with clinically probable DLB. Regression modeling examined the unique and shared contribution of each pathology to the variance of illness duration.<h4>Results</h4>Patient  ...[more]

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