Nuclear Factor-kappaB in Autoimmunity: Man and Mouse.
Ontology highlight
ABSTRACT:
SUBMITTER: Miraghazadeh B
PROVIDER: S-EPMC5900062 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Publications
Nuclear Factor-kappaB in Autoimmunity: Man and Mouse.
Miraghazadeh Bahar B Cook Matthew C MC
Frontiers in immunology 20180409
NF-κB (nuclear factor-kappa B) is a transcription complex crucial for host defense mediated by innate and adaptive immunity, where canonical NF-κB signaling, mediated by nuclear translocation of RelA, c-Rel, and p50, is important for immune cell activation, differentiation, and survival. Non-canonical signaling mediated by nuclear translocation of p52 and RelB contributes to lymphocyte maturation and survival and is also crucial for lymphoid organogenesis. We outline NF-κB signaling and regulati ...[more]
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