Ontology highlight
ABSTRACT:
SUBMITTER: Gayathri T
PROVIDER: S-EPMC5900332 | biostudies-literature | 2018 Apr
REPOSITORIES: biostudies-literature
Gayathri Thumuganti T Vijayalakshmi A A Mangalath Sreejith S Joseph Joshy J Rao N Madhusudhana NM Singh Surya Prakash SP
ACS medicinal chemistry letters 20180204 4
We report a series of four efficient photosensitizers (PSs) based on a Bodipy core for photodynamic therapy (PDT). In the absence of hydrophilic functional groups, these PSs have been encapsulated in liposomes and examined for photocytotoxicity against human ovarian carcinoma cell line (SK-OV-3). The IC<sub>50</sub> values obtained are as low as 0.350 μM, which compete with the classical photosensitizer chlorine E6 (IC<sub>50</sub> = 0.39 μM) under similar experimental conditions. ...[more]