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Study on Liposomal Encapsulation of New Bodipy Sensitizers for Photodynamic Therapy.


ABSTRACT: We report a series of four efficient photosensitizers (PSs) based on a Bodipy core for photodynamic therapy (PDT). In the absence of hydrophilic functional groups, these PSs have been encapsulated in liposomes and examined for photocytotoxicity against human ovarian carcinoma cell line (SK-OV-3). The IC50 values obtained are as low as 0.350 ?M, which compete with the classical photosensitizer chlorine E6 (IC50 = 0.39 ?M) under similar experimental conditions.

SUBMITTER: Gayathri T 

PROVIDER: S-EPMC5900332 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature

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Study on Liposomal Encapsulation of New Bodipy Sensitizers for Photodynamic Therapy.

Gayathri Thumuganti T   Vijayalakshmi A A   Mangalath Sreejith S   Joseph Joshy J   Rao N Madhusudhana NM   Singh Surya Prakash SP  

ACS medicinal chemistry letters 20180204 4


We report a series of four efficient photosensitizers (PSs) based on a Bodipy core for photodynamic therapy (PDT). In the absence of hydrophilic functional groups, these PSs have been encapsulated in liposomes and examined for photocytotoxicity against human ovarian carcinoma cell line (SK-OV-3). The IC<sub>50</sub> values obtained are as low as 0.350 μM, which compete with the classical photosensitizer chlorine E6 (IC<sub>50</sub> = 0.39 μM) under similar experimental conditions. ...[more]

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