Ontology highlight
ABSTRACT:
SUBMITTER: Avansini SH
PROVIDER: S-EPMC5901021 | biostudies-literature | 2018 Mar
REPOSITORIES: biostudies-literature
Avansini Simoni H SH Torres Fábio R FR Vieira André S AS Dogini Danyella B DB Rogerio Fabio F Coan Ana C AC Morita Marcia E ME Guerreiro Marilisa M MM Yasuda Clarissa L CL Secolin Rodrigo R Carvalho Benilton S BS Borges Murilo G MG Almeida Vanessa S VS Araújo Patrícia A O R PAOR Queiroz Luciano L Cendes Fernando F Lopes-Cendes Iscia I
Annals of neurology 20180310 3
<h4>Objective</h4>Focal cortical dysplasias (FCDs) are an important cause of drug-resistant epilepsy. In this work, we aimed to investigate whether abnormal gene regulation, mediated by microRNA, could be involved in FCD type II.<h4>Methods</h4>We used total RNA from the brain tissue of 16 patients with FCD type II and 28 controls. MicroRNA expression was initially assessed by microarray. Quantitative polymerase chain reaction, in situ hybridization, luciferase reporter assays, and deep sequenci ...[more]