Ontology highlight
ABSTRACT:
SUBMITTER: Cykowski MD
PROVIDER: S-EPMC5901081 | biostudies-literature | 2017 May
REPOSITORIES: biostudies-literature
Cykowski Matthew D MD Powell Suzanne Z SZ Peterson Leif E LE Appel Joan W JW Rivera Andreana L AL Takei Hidehiro H Chang Ellen E Appel Stanley H SH
Journal of neuropathology and experimental neurology 20170501 5
To determine the significance of TAR DNA binding protein 43 kDa (TDP-43) pathology in amyotrophic lateral sclerosis (ALS), we examined the whole brains and spinal cords of 57 patients (35 men; 22 women; mean age 63.3 years; 15 patients with c9orf72-associated ALS [c9ALS]). TDP-43 pathologic burden was determined relative to symptom onset site, disease duration, progression rate, cognitive status, and c9ALS status. There was a trend for greater TDP-43 pathologic burden in cognitively impaired pat ...[more]