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Molecular control of Rab activity by GEFs, GAPs and GDI.

ABSTRACT: Rab proteins are the major regulators of vesicular trafficking in eukaryotic cells. Their activity can be tightly controlled within cells: Regulated by guanine nucleotide exchange factors (GEFs) and GTPase activating proteins (GAPs), they switch between an active GTP-bound state and an inactive GDP-bound state, interacting with downstream effector proteins only in the active state. Additionally, they can bind to membranes via C-terminal prenylated cysteine residues and they can be solubilized and shuttled between membranes by chaperone-like molecules called GDP dissociation inhibitors (GDIs). In this review we give an overview of Rab proteins with a focus on the current understanding of their regulation by GEFs, GAPs and GDI.

SUBMITTER: Muller MP

PROVIDER: S-EPMC5902221 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature

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Molecular control of Rab activity by GEFs, GAPs and GDI.

Müller Matthias P MP Goody Roger S RS

Small GTPases 20170201 1-2

Rab proteins are the major regulators of vesicular trafficking in eukaryotic cells. Their activity can be tightly controlled within cells: Regulated by guanine nucleotide exchange factors (GEFs) and GTPase activating proteins (GAPs), they switch between an active GTP-bound state and an inactive GDP-bound state, interacting with downstream effector proteins only in the active state. Additionally, they can bind to membranes via C-terminal prenylated cysteine residues and they can be solubilized an ...[more]

PMID: 28055292

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