Ontology highlight
ABSTRACT:
SUBMITTER: Ding S
PROVIDER: S-EPMC5902600 | biostudies-literature | 2018 Apr
REPOSITORIES: biostudies-literature
Ding Siyuan S Diep Jonathan J Feng Ningguo N Ren Lili L Li Bin B Ooi Yaw Shin YS Wang Xin X Brulois Kevin F KF Yasukawa Linda L LL Li Xingnan X Kuo Calvin J CJ Solomon David A DA Carette Jan E JE Greenberg Harry B HB
Nature communications 20180416 1
Cohesin is a multi-subunit nuclear protein complex that coordinates sister chromatid separation during cell division. Highly frequent somatic mutations in genes encoding core cohesin subunits have been reported in multiple cancer types. Here, using a genome-wide CRISPR-Cas9 screening approach to identify host dependency factors and novel innate immune regulators of rotavirus (RV) infection, we demonstrate that the loss of STAG2, an important component of the cohesin complex, confers resistance t ...[more]