Ontology highlight
ABSTRACT:
SUBMITTER: Howard DM
PROVIDER: S-EPMC5902628 | biostudies-literature | 2018 Apr
REPOSITORIES: biostudies-literature
Howard David M DM Adams Mark J MJ Shirali Masoud M Clarke Toni-Kim TK Marioni Riccardo E RE Davies Gail G Coleman Jonathan R I JRI Alloza Clara C Shen Xueyi X Barbu Miruna C MC Wigmore Eleanor M EM Gibson Jude J Hagenaars Saskia P SP Lewis Cathryn M CM Ward Joey J Smith Daniel J DJ Sullivan Patrick F PF Haley Chris S CS Breen Gerome G Deary Ian J IJ McIntosh Andrew M AM
Nature communications 20180416 1
Depression is a polygenic trait that causes extensive periods of disability. Previous genetic studies have identified common risk variants which have progressively increased in number with increasing sample sizes of the respective studies. Here, we conduct a genome-wide association study in 322,580 UK Biobank participants for three depression-related phenotypes: broad depression, probable major depressive disorder (MDD), and International Classification of Diseases (ICD, version 9 or 10)-coded M ...[more]