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Unmanipulated haploidentical in comparison with matched unrelated donor stem cell transplantation in patients 60 years and older with acute myeloid leukemia: a comparative study on behalf of the ALWP of the EBMT.

ABSTRACT: BACKGROUND:Acute myeloid leukemia (AML) is both more common and with more biologically aggressive phenotype in the elderly. Allogenic stem cell transplantation (allo-SCT) is the best treatment option in fit patients. Either HLA-matched unrelated donor (MUD) or haploidentical (Haplo) donor are possible alternative for patients in need. METHODS:We retrospectively compared non-T-cell-depleted Haplo (n?=?250) to 10/10 MUD (n?=?2589) in AML patients ??60 years. RESULTS:Median follow-up was 23 months. Disease status at transplant differs significantly between the two groups (p?

SUBMITTER: Santoro N 

PROVIDER: S-EPMC5902953 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature

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Unmanipulated haploidentical in comparison with matched unrelated donor stem cell transplantation in patients 60 years and older with acute myeloid leukemia: a comparative study on behalf of the ALWP of the EBMT.

Santoro Nicole N   Labopin Myriam M   Giannotti Federica F   Ehninger Gerard G   Niederwieser Dietger D   Brecht Arne A   Stelljes Matthias M   Kröger Nicolaus N   Einsele Herman H   Eder Matthias M   Hallek Michael M   Glass Bertram B   Finke Jürgen J   Ciceri Fabio F   Mohty Mohamad M   Ruggeri Annalisa A   Nagler Arnon A  

Journal of hematology & oncology 20180416 1

<h4>Background</h4>Acute myeloid leukemia (AML) is both more common and with more biologically aggressive phenotype in the elderly. Allogenic stem cell transplantation (allo-SCT) is the best treatment option in fit patients. Either HLA-matched unrelated donor (MUD) or haploidentical (Haplo) donor are possible alternative for patients in need.<h4>Methods</h4>We retrospectively compared non-T-cell-depleted Haplo (n = 250) to 10/10 MUD (n = 2589) in AML patients ≥ 60 years.<h4>Results</h4>Median fo  ...[more]

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