Ontology highlight
ABSTRACT:
SUBMITTER: Zhang Y
PROVIDER: S-EPMC5903315 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Zhang Yingying Y Zhao Siqi S Wu Depei D Liu Xingmei X Shi Mingjun M Wang Yuanyuan Y Zhang Fan F Ding Jing J Xiao Ying Y Guo Bing B Guo Bing B
Journal of diabetes research 20180403
Renal tubulointerstitial fibrosis (TIF) is a major feature of diabetic nephropathy (DN). There is increasing evidence demonstrating that microRNAs act as key players in the regulation of autophagy and are involved in DN. However, the exact link among microRNAs, autophagy, and TIF in DN is largely unknown. In this study, our results showed that TIF was observed in DN rats together with obvious autophagy suppression. Moreover, microRNA-22 (miR-22) was upregulated and associated with reduced expres ...[more]