Ontology highlight
ABSTRACT:
SUBMITTER: Battu S
PROVIDER: S-EPMC5903674 | biostudies-literature | 2018 Apr
REPOSITORIES: biostudies-literature
Battu Srikanth S Afroz Sumbul S Giddaluru Jeevan J Naz Saima S Huang Weishan W Khumukcham Saratchandra Singh SS Khan Rafiq Ahmad RA Bhat Saleem Yousuf SY Qureshi Insaf Ahmed IA Manavathi Bramanandam B Khan Aleem Ahmed AA August Avery A Hasnain Seyed Ehtesham SE Khan Nooruddin N
PLoS biology 20180405 4
Activation of the amino acid starvation response (AAR) increases lifespan and acute stress resistance as well as regulates inflammation. However, the underlying mechanisms remain unclear. Here, we show that activation of AAR pharmacologically by Halofuginone (HF) significantly inhibits production of the proinflammatory cytokine interleukin 1β (IL-1β) and provides protection from intestinal inflammation in mice. HF inhibits IL-1β through general control nonderepressible 2 kinase (GCN2)-dependent ...[more]