Evidence of amyloid-? cerebral amyloid angiopathy transmission through neurosurgery.
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ABSTRACT:
SUBMITTER: Jaunmuktane Z
PROVIDER: S-EPMC5904220 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
Publications
Evidence of amyloid-β cerebral amyloid angiopathy transmission through neurosurgery.
Jaunmuktane Zane Z Quaegebeur Annelies A Taipa Ricardo R Viana-Baptista Miguel M Barbosa Raquel R Koriath Carolin C Sciot Raf R Mead Simon S Brandner Sebastian S
Acta neuropathologica 20180215 5
Amyloid-β (Aβ) is a peptide deposited in the brain parenchyma in Alzheimer's disease and in cerebral blood vessels, causing cerebral amyloid angiopathy (CAA). Aβ pathology is transmissible experimentally in animals and through medical procedures in humans, such as contaminated growth hormone or dura mater transplantation in the context of iatrogenic prion disease. Here, we present four patients who underwent neurosurgical procedures during childhood or teenage years and presented with intracereb ...[more]
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