Ontology highlight
ABSTRACT:
SUBMITTER: Kim SY
PROVIDER: S-EPMC5904255 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Kim Sook Young SY Son Myoungsun M Lee Sang Eun SE Park In Ho IH Kwak Man Sup MS Han Myeonggil M Lee Hyun Sook HS Kim Eun Sook ES Kim Jae-Young JY Lee Jong Eun JE Choi Ji Eun JE Diamond Betty B Shin Jeon-Soo JS
Frontiers in immunology 20180411
High-mobility group box 1 (HMGB1), a well-known danger-associated molecular pattern molecule, acts as a pro-inflammatory molecule when secreted by activated immune cells or released after necrotic cell damage. HMGB1 binds to immunogenic bacterial components and augments septic inflammation. In this study, we show how HMGB1 mediates complement activation, promoting sterile inflammation. We show that HMGB1 activates the classical pathway of complement system in an antibody-independent manner after ...[more]