Ontology highlight
ABSTRACT:
SUBMITTER: Riedl B
PROVIDER: S-EPMC5905266 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Riedl Bettina B Schmid Walther W
Beilstein journal of organic chemistry 20180413
Synthetic approaches towards <i>N</i>-acetylgalactosamine (GalNAc) have been attracting considerable interest since this compound is known for its pivotal role in cell-cell interaction and receptor induced cell signaling. Herein, we present a synthetic route in which two of the four stereogenic centers present in the target compound are derived from enantiopure tartaric acid being selectively converted to epoxy alcohols. The key step is the Pd-catalyzed, stereo- and regioselective epoxide openin ...[more]