Ontology highlight
ABSTRACT:
SUBMITTER: Bauerle KT
PROVIDER: S-EPMC5905394 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
Bauerle Kevin T KT Hutson Irina I Scheller Erica L EL Harris Charles A CA
Endocrinology 20180501 5
Regulation of adipogenesis is of major interest given that adipose tissue expansion and dysfunction are central to metabolic syndrome. Glucocorticoids (GCs) are important for adipogenesis in vitro. However, establishing a role for GCs in adipogenesis in vivo has been difficult. GC receptor (GR)‒null mice die at birth, a time at which wild-type (WT) mice do not have fully developed white adipose depots. We conducted several studies aimed at defining the role of GC signaling in adipogenesis in vit ...[more]