Ontology highlight
ABSTRACT:
SUBMITTER: Houghton D
PROVIDER: S-EPMC5905657 | biostudies-literature | 2018 Apr
REPOSITORIES: biostudies-literature
Houghton David D Stewart Christopher J CJ Stamp Craig C Nelson Andrew A Aj Ami Nadim J NJ Petrosino Joseph F JF Wipat Anil A Trenell Michael I MI Turnbull Douglass M DM Greaves Laura C LC
The journals of gerontology. Series A, Biological sciences and medical sciences 20180401 5
Mitochondrial dysfunction is prevalent in the aging gastrointestinal tract. We investigated whether mitochondrial function in aging colonic crypts and exercise influences microbial gut communities in mice. Twelve PolgAmut/mut mice were randomly divided into a sedentary and exercise group at 4 months. Seven-aged matched PolgA+/+ mice remained sedentary throughout. Stool samples were collected at 4, 7, and 11 months, and bacterial profiling was achieved through 16S rRNA sequencing profiling. Mitoc ...[more]