Ontology highlight
ABSTRACT:
SUBMITTER: Williams LD
PROVIDER: S-EPMC5905719 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
Science immunology 20170101 7
Induction of broadly neutralizing antibodies (bnAbs) is a goal of HIV-1 vaccine development. Antibody 10E8, reactive with the distal portion of the membrane-proximal external region (MPER) of HIV-1 gp41, is broadly neutralizing. However, the ontogeny of distal MPER antibodies and the relationship of memory B cell to plasma bnAbs are poorly understood. HIV-1-specific memory B cell flow sorting and proteomic identification of anti-MPER plasma antibodies from an HIV-1-infected individual were used ...[more]