Ontology highlight
ABSTRACT:
SUBMITTER: Sanchez-Valdez FJ
PROVIDER: S-EPMC5906098 | biostudies-literature | 2018 Mar
REPOSITORIES: biostudies-literature
Sánchez-Valdéz Fernando J FJ Padilla Angel A Wang Wei W Orr Dylan D Tarleton Rick L RL
eLife 20180326
The ability of the Chagas disease agent <i>Trypanosoma cruzi</i> to resist extended in vivo exposure to highly effective trypanocidal compounds prompted us to explore the potential for dormancy and its contribution to failed drug treatments in this infection. We document the development of non-proliferating intracellular amastigotes in vivo and in vitro in the absence of drug treatment. Non-proliferative amastigotes ultimately converted to trypomastigotes and established infections in new host c ...[more]