Ontology highlight
ABSTRACT:
SUBMITTER: Chukwu JE
PROVIDER: S-EPMC5906480 | biostudies-literature | 2018 Apr
REPOSITORIES: biostudies-literature
Chukwu Jessica E JE Pedersen Jan T JT Pedersen Lars Ø LØ Volbracht Christiane C Sigurdsson Einar M EM Kong Xiang-Peng XP
Scientific reports 20180418 1
Tau antibodies have shown therapeutic potential for Alzheimer's disease and several are in clinical trials. As a microtubule-associated protein, tau relies on dynamic phosphorylation for its normal functions. In tauopathies, it becomes hyperphosphorylated and aggregates into toxic assemblies, which collectively lead to neurodegeneration. Of the phospho-epitopes, the region around Ser396 has received particular attention because of its prominence and stability in tauopathies. Here we report the f ...[more]