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Regioselective synthesis of pyridines by redox alkylation of pyridine N-oxides with malonates.

ABSTRACT:

Abstract

A regioselective synthesis of pyridines by the addition of malonate anions to pyridine N-oxide derivatives, which have been activated by trifluoromethanesulfonic anhydride, is reported. The reaction selectively affords either 2- or 4-substituted pyridines in good yields.

Graphical abstract

SUBMITTER: Lemmerer M

PROVIDER: S-EPMC5906502 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature

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Regioselective synthesis of pyridines by redox alkylation of pyridine <i>N</i>-oxides with malonates.

Lemmerer Miran M Teskey Christopher J CJ Kaiser Daniel D Maulide Nuno N

Monatshefte fur chemie 20171128 4

<h4>Abstract</h4>A regioselective synthesis of pyridines by the addition of malonate anions to pyridine <i>N</i>-oxide derivatives, which have been activated by trifluoromethanesulfonic anhydride, is reported. The reaction selectively affords either 2- or 4-substituted pyridines in good yields.<h4>Graphical abstract</h4> ...[more]

PMID: 29681655

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