Ontology highlight
ABSTRACT:
SUBMITTER: Pircher J
PROVIDER: S-EPMC5906636 | biostudies-literature | 2018 Apr
REPOSITORIES: biostudies-literature
Pircher Joachim J Czermak Thomas T Ehrlich Andreas A Eberle Clemens C Gaitzsch Erik E Margraf Andreas A Grommes Jochen J Saha Prakash P Titova Anna A Ishikawa-Ankerhold Hellen H Stark Konstantin K Petzold Tobias T Stocker Thomas T Weckbach Ludwig T LT Novotny Julia J Sperandio Markus M Nieswandt Bernhard B Smith Alberto A Mannell Hanna H Walzog Barbara B Horst David D Soehnlein Oliver O Massberg Steffen S Schulz Christian C Schulz Christian C
Nature communications 20180418 1
Leukocyte-released antimicrobial peptides contribute to pathogen elimination and activation of the immune system. Their role in thrombosis is incompletely understood. Here we show that the cathelicidin LL-37 is abundant in thrombi from patients with acute myocardial infarction. Its mouse homologue, CRAMP, is present in mouse arterial thrombi following vascular injury, and derives mainly from circulating neutrophils. Absence of hematopoietic CRAMP in bone marrow chimeric mice reduces platelet rec ...[more]