A multifunctional targeting probe with dual-mode imaging and photothermal therapy used in vivo.

ABSTRACT:

Background

Ag₂S has the characteristics of conventional quantum dot such as broad excitation spectrum, narrow emission spectrum, long fluorescence lifetime, strong anti-bleaching ability, and other optical properties. Moreover, since its fluorescence emission is located in the NIR-II region, has stronger penetrating ability for tissue. Ag₂S quantum dot has strong absorption during the visible and NIR regions, it has good photothermal and photoacoustic response under certain wavelength excitation.

Results

200 nm aqueous probe Ag₂S@DSPE-PEG₂₀₀₀-FA (Ag₂S@DP-FA) with good dispersibility and stability was prepared by coating hydrophobic Ag₂S with the mixture of folic acid (FA) modified DSPE-PEG₂₀₀₀ (DP)

SUBMITTER: Zhang XS 

PROVIDER: S-EPMC5907178 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature