Dataset Information

Local- and regional-scale air pollution modelling (PM10) and exposure assessment for pregnancy trimesters, infancy, and childhood to age 15?years: Avon Longitudinal Study of Parents And Children (ALSPAC).

ABSTRACT: We established air pollution modelling to study particle (PM10) exposures during pregnancy and infancy (1990-1993) through childhood and adolescence up to age ~15?years (1991-2008) for the Avon Longitudinal Study of Parents And Children (ALSPAC) birth cohort. For pregnancy trimesters and infancy (birth to 6?months; 7 to 12?months) we used local (ADMS-Urban) and regional/long-range (NAME-III) air pollution models, with a model constant for local, non-anthropogenic sources. For longer exposure periods (annually and the average of birth to age ~8 and to age ~15?years to coincide with relevant follow-up clinics) we assessed spatial contrasts in local sources of PM10 with a yearly-varying concentration for all background sources. We modelled PM10 (?g/m3) for 36,986 address locations over 19?years and then accounted for changes in address in calculating exposures for different periods: trimesters/infancy (n?=?11,929); each year of life to age ~15 (n?=?10,383). Intra-subject exposure contrasts were largest between pregnancy trimesters (5th to 95th centile: 24.4-37.3??g/m3) and mostly related to temporal variability in regional/long-range PM10. PM10 exposures fell on average by 11.6??g/m3 from first year of life (mean concentration?=?31.2??g/m3) to age ~15 (mean?=?19.6??g/m3), and 5.4??g/m3 between follow-up clinics (age ~8 to age ~15). Spatial contrasts in 8-year average PM10 exposures (5th to 95th centile) were relatively low: 25.4-30.0??g/m3 to age ~8?years and 20.7-23.9??g/m3 from age ~8 to age ~15?years. The contribution of local sources to total PM10 was 18.5%-19.5% during pregnancy and infancy, and 14.4%-17.0% for periods leading up to follow-up clinics. Main roads within the study area contributed on average ~3.0% to total PM10 exposures in all periods; 9.5% of address locations were within 50?m of a main road. Exposure estimates will be used in a number of planned epidemiological studies.

SUBMITTER: Gulliver J

PROVIDER: S-EPMC5907299 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature

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Local- and regional-scale air pollution modelling (PM<sub>10</sub>) and exposure assessment for pregnancy trimesters, infancy, and childhood to age 15 years: Avon Longitudinal Study of Parents And Children (ALSPAC).

Gulliver John J Elliott Paul P Henderson John J Hansell Anna L AL Vienneau Danielle D Cai Yutong Y McCrea Adrienne A Garwood Kevin K Boyd Andy A Neal Lucy L Agnew Paul P Fecht Daniela D Briggs David D de Hoogh Kees K

Environment international 20180128

We established air pollution modelling to study particle (PM<sub>10</sub>) exposures during pregnancy and infancy (1990-1993) through childhood and adolescence up to age ~15 years (1991-2008) for the Avon Longitudinal Study of Parents And Children (ALSPAC) birth cohort. For pregnancy trimesters and infancy (birth to 6 months; 7 to 12 months) we used local (ADMS-Urban) and regional/long-range (NAME-III) air pollution models, with a model constant for local, non-anthropogenic sources. For longer e ...[more]

PMID: 29421397

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Project description:BackgroundEvidence suggests that exposure to particulate matter with aerodynamic diameter less than 10 μm (PM10) is associated with reduced birth weight, but information is limited on the sources of PM10 and exposure misclassification from assigning exposures to place of residence at birth.MethodsTrimester and source-specific PM10 exposures (PM10 from road source, local non-road source, and total source) in pregnancy were estimated using dispersion models and a full maternal residential history for 12,020 births from the Avon longitudinal study of parents and children (ALSPAC) cohort in 1990-1992 in the Bristol area. Information on birth outcomes were obtained from birth records. Maternal sociodemographic and lifestyle factors were obtained from questionnaires. We used linear regression models for continuous outcomes (birth weight, head circumference (HC), and birth length (BL) and logistic regression models for binary outcomes (preterm birth (PTB), term low birth weight (TLBW) and small for gestational age (SGA)). Sensitivity analysis was performed using multiple imputation for missing covariate data.ResultsAfter adjustment, interquartile range increases in source specific PM10 from traffic were associated with 17 to 18% increased odds of TLBW in all pregnancy periods. We also found odds of TLBW increased by 40% (OR: 1.40, 95%CI: 1.12, 1.75) and odds of SGA increased by 18% (OR: 1.18, 95%CI: 1.05, 1.32) per IQR (6.54 μg/m3) increase of total PM10 exposure in the third trimester.ConclusionThis study adds to evidence that maternal PM10 exposures affect birth weight, with particular concern in relation to exposures to PM10 from road transport sources; results for total PM10 suggest greatest effect in the third trimester. Effect size estimates relate to exposures in the 1990s and are higher than those for recent studies - this may relate to reduced exposure misclassification through use of full residential history information, changes in air pollution toxicity over time and/or residual confounding.

Dataset Information

Local- and regional-scale air pollution modelling (PM10) and exposure assessment for pregnancy trimesters, infancy, and childhood to age 15?years: Avon Longitudinal Study of Parents And Children (ALSPAC).

Publications

Local- and regional-scale air pollution modelling (PM<sub>10</sub>) and exposure assessment for pregnancy trimesters, infancy, and childhood to age 15 years: Avon Longitudinal Study of Parents And Children (ALSPAC).

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Dataset Information

Local- and regional-scale air pollution modelling (PM10) and exposure assessment for pregnancy trimesters, infancy, and childhood to age 15?years: Avon Longitudinal Study of Parents And Children (ALSPAC).

Publications

Local- and regional-scale air pollution modelling (PM<sub>10</sub>) and exposure assessment for pregnancy trimesters, infancy, and childhood to age 15 years: Avon Longitudinal Study of Parents And Children (ALSPAC).

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets

Local- and regional-scale air pollution modelling (PM<sub>10</sub>) and exposure assessment for pregnancy trimesters, infancy, and childhood to age 15 years: Avon Longitudinal Study of Parents And Children (ALSPAC).