Ontology highlight
ABSTRACT:
SUBMITTER: Bos R
PROVIDER: S-EPMC5907934 | biostudies-literature | 2018 Mar
REPOSITORIES: biostudies-literature
Bos Rémi R Harris-Warrick Ronald M RM Brocard Cécile C Demianenko Liliia E LE Manuel Marin M Zytnicki Daniel D Korogod Sergiy M SM Brocard Frédéric F
Cell reports 20180301 12
Spinal motoneurons are endowed with nonlinear spiking behaviors manifested by a spike acceleration whose functional significance remains uncertain. Here, we show in rodent lumbar motoneurons that these nonlinear spiking properties do not rely only on activation of dendritic nifedipine-sensitive L-type Ca<sup>2+</sup> channels, as assumed for decades, but also on the slow inactivation of a nifedipine-sensitive K<sup>+</sup> current mediated by Kv1.2 channels that are highly expressed in axon init ...[more]