Ontology highlight
ABSTRACT:
SUBMITTER: Lin HK
PROVIDER: S-EPMC5908114 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
Journal of cellular and molecular medicine 20180304 5
Caveolin-1 (Cav1) is down-regulated during MK4 (MDCK cells harbouring inducible Ha-Ras<sup>V12</sup> gene) transformation by Ha-Ras<sup>V12</sup> . Cav1 overexpression abrogates the Ha-Ras<sup>V12</sup> -driven transformation of MK4 cells; however, the targeted down-regulation of Cav1 is not sufficient to mimic this transformation. Cav1-silenced cells, including MK4/shCav1 cells and MDCK/shCav1 cells, showed an increased cell area and discontinuous junction-related proteins staining. Cellular an ...[more]