Ontology highlight
ABSTRACT:
SUBMITTER: Xie T
PROVIDER: S-EPMC5908225 | biostudies-literature | 2018 Mar
REPOSITORIES: biostudies-literature
Cell reports 20180301 13
Fibroblast heterogeneity has long been recognized in mouse and human lungs, homeostasis, and disease states. However, there is no common consensus on fibroblast subtypes, lineages, biological properties, signaling, and plasticity, which severely hampers our understanding of the mechanisms of fibrosis. To comprehensively classify fibroblast populations in the lung using an unbiased approach, single-cell RNA sequencing was performed with mesenchymal preparations from either uninjured or bleomycin- ...[more]