Unknown

Dataset Information

0

Systematic review and meta-analysis of the prognostic significance of microRNAs in cervical cancer.


ABSTRACT: In this meta-analysis, we analyzed case-control studies that assessed the prognostic potential of miRNAs in cervical cancer. We comprehensively searched EMBASE and PubMed databases and enrolled seven studies with 445 cervical cancer cases. A fixed effects model was used to calculate pooled hazard ratios (HRs) and associated 95% confidence intervals (95% CIs) from the overall survival (OS) data. Our analysis showed that poor OS in cervical cancer was associated with low miR-125 expression (HR = 1.61, 95% CI: 1.02-2.55, P = 0.042; I2 = 10.1%, P = 0.292; n = 99), low miR-145 expression (HR = 1.70, 95% CI: 1.29-2.24, P < 0.001; I2 = 0%, P = 0.560; n = 193) and high miR-196 expression (HR = 0.28, 95% CI: 0.15-0.52, P < 0.001; I2 = 0%, P = 0.950, n = 197). This makes microRNAs such as miR-125, miR-145 and miR-196 potential prognostic biomarkers in cervical cancer.

SUBMITTER: Chen Z 

PROVIDER: S-EPMC5908312 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature

altmetric image

Publications

Systematic review and meta-analysis of the prognostic significance of microRNAs in cervical cancer.

Chen Zhilan Z   Han Yingyan Y   Song Chengwen C   Wei Huafang H   Chen Ying Y   Huang Kecheng K   Li Shuang S   Ma Ding D   Wang Shixuan S   Wang Jing J   Lu Qiping Q  

Oncotarget 20171216 24


In this meta-analysis, we analyzed case-control studies that assessed the prognostic potential of miRNAs in cervical cancer. We comprehensively searched EMBASE and PubMed databases and enrolled seven studies with 445 cervical cancer cases. A fixed effects model was used to calculate pooled hazard ratios (HRs) and associated 95% confidence intervals (95% CIs) from the overall survival (OS) data. Our analysis showed that poor OS in cervical cancer was associated with low miR-125 expression (HR = 1  ...[more]

Similar Datasets

| S-EPMC6457304 | biostudies-literature
| S-EPMC5668020 | biostudies-literature
| 2654299 | ecrin-mdr-crc
| S-EPMC6313946 | biostudies-other
| S-EPMC5369999 | biostudies-literature
| S-EPMC7788830 | biostudies-literature
| S-EPMC5542297 | biostudies-literature
| S-EPMC7445175 | biostudies-literature
| S-EPMC6992676 | biostudies-literature
| S-EPMC6890323 | biostudies-literature