Oxidation-induced generation of a mild electrophile for proximity-enhanced protein-protein crosslinking.
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ABSTRACT:
SUBMITTER: Shang X
PROVIDER: S-EPMC5908726 | biostudies-literature | 2018 Apr
REPOSITORIES: biostudies-literature
Publications
Oxidation-induced generation of a mild electrophile for proximity-enhanced protein-protein crosslinking.
Shang X X Chen Y Y Wang N N Niu W W Guo J J
Chemical communications (Cambridge, England) 20180401 33
We report a strategy to introduce a reactive electrophile into proteins through the conversion of a chemically inert group into a bioreactive group in response to an inducer molecule. This strategy was demonstrated by oxidation-induced and proximity-enhanced protein-protein crosslinking in the presence of a large excess of free nucleophile. ...[more]
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